Should we systematically perform central nervous system imaging in patients with Whipple's endocarditis?
Identifieur interne : 000245 ( France/Analysis ); précédent : 000244; suivant : 000246Should we systematically perform central nervous system imaging in patients with Whipple's endocarditis?
Auteurs : Sophie Besnard [France] ; Anne Cady [France] ; Erwan Flecher [France] ; Fabien Fily [France] ; Matthieu Revest [France] ; Cédric Arvieux [France] ; Pierre-Yves Donnio [France] ; Christian Michelet [France] ; Pierre Tattevin [France]Source :
English descriptors
Abstract
BACKGROUND: Whipple's endocarditis is an uncommon disease, with approximately 100 cases reported to date. Case series suggest that Whipple's endocarditis usually presents without extracardiac manifestations of Whipple's disease. METHODS: We report 4 consecutive cases of Whipple's endocarditis associated with brain lesions. All patients fulfilled Duke Criteria for definite endocarditis. Whipple's disease was diagnosed through 16S rRNA polymerase chain reaction assays on valves excised from patients with culture-negative endocarditis (n=3) or through polymerase chain reaction and periodic acid staining-positive foamy macrophages on duodenal biopsy (n=1). RESULTS: All patients were male, aged 56 to 72 years. They presented with mitral (n=1), aortic (n=1), mitral and aortic (n=1), and tricuspid (n=1) endocarditis. Brain magnetic resonance imaging was performed because of mild-to-moderate cognitive disorders (n=3) or ataxia (n=1) and revealed multiple (n=3) or solitary (n=1) contrast-enhancing lesions. Cerebrospinal fluid studies revealed meningitis in 1 case. Polymerase chain reaction assays on cerebrospinal fluid were negative for all patients. All patients received intravenous ceftriaxone (2-4 weeks) associated with gentamicin (2 weeks), followed by 1 year of oral trimethoprim-sulfamethoxazole, with favorable outcomes. CONCLUSION: Whipple's associated central nervous system disease may be common but frequently undiagnosed, in patients with Whipple's endocarditis. Because treatment is different when neurologic disease is present (ie, trimethoprim-sulfamethoxazole vs doxycycline/hydroxychloroquine), clinicians should consider brain imaging in patients diagnosed with Whipple's endocarditis.
Url:
DOI: 10.1016/j.amjmed.2010.04.030
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Hal, to step Corpus: 000215
- to stream Hal, to step Curation: 000215
- to stream Hal, to step Checkpoint: 000177
- to stream Main, to step Merge: 001605
- to stream Main, to step Curation: 001603
- to stream Main, to step Exploration: 001603
- to stream France, to step Extraction: 000245
Links to Exploration step
Hal:hal-00759192Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Should we systematically perform central nervous system imaging in patients with Whipple's endocarditis?</title>
<author><name sortKey="Besnard, Sophie" sort="Besnard, Sophie" uniqKey="Besnard S" first="Sophie" last="Besnard">Sophie Besnard</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-17929" status="VALID"> <orgName>Service des maladies infectieuses et réanimation médicale</orgName>
<desc> <address> <addrLine>2 rue Henri Le Guilloux 35033 RENNES cedex 9</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.chu-rennes.fr/</ref>
</desc>
<listRelation> <relation active="#struct-105160" type="direct"></relation>
<relation active="#struct-528860" type="indirect"></relation>
<relation active="#struct-300129" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-105160" type="direct"><org type="institution" xml:id="struct-105160" status="VALID"> <orgName>Université de Rennes 1</orgName>
<orgName type="acronym">UR1</orgName>
<desc> <address> <addrLine>2 rue du Thabor - CS 46510 - 35065 Rennes cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-rennes1.fr/</ref>
</desc>
<listRelation> <relation active="#struct-528860" type="direct"></relation>
</listRelation>
</org>
</tutelle>
<tutelle active="#struct-528860" type="indirect"><org type="regroupinstitution" xml:id="struct-528860" status="VALID"> <orgName>Université de Rennes</orgName>
<orgName type="acronym">UNIV-RENNES</orgName>
<date type="start">2018-01-01</date>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300129" type="direct"><org type="institution" xml:id="struct-300129" status="VALID"> <orgName>Hôpital Pontchaillou</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Rennes</settlement>
<region type="region" nuts="2">Région Bretagne</region>
</placeName>
<orgName type="university">Université de Rennes 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université européenne de Bretagne</orgName>
</affiliation>
</author>
<author><name sortKey="Cady, Anne" sort="Cady, Anne" uniqKey="Cady A" first="Anne" last="Cady">Anne Cady</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-104640" status="OLD"> <idno type="IdRef">185720005</idno>
<idno type="ISNI">0000 0004 0450 5866 </idno>
<idno type="RNSR">199213399D</idno>
<orgName>Microbiologie : Risques Infectieux</orgName>
<date type="start">1992</date>
<date type="end">2016-12-31</date>
<desc> <address> <addrLine>UFR Sciences Pharmaceutiques et Biologiques, Département de Bactériologie Virologie et Hygiène Hospitalière - 2 avenue du Professeur Léon Bernard (Bât 15) 35043 Rennes</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://microbiologie.univ-rennes1.fr/</ref>
</desc>
<listRelation> <relation name="EA1254" active="#struct-105160" type="direct"></relation>
<relation active="#struct-528860" type="indirect"></relation>
<relation active="#struct-301327" type="direct"></relation>
<relation active="#struct-303578" type="direct"></relation>
<relation active="#struct-305263" type="direct"></relation>
<relation active="#struct-453207" type="direct"></relation>
</listRelation>
<tutelles><tutelle name="EA1254" active="#struct-105160" type="direct"><org type="institution" xml:id="struct-105160" status="VALID"> <orgName>Université de Rennes 1</orgName>
<orgName type="acronym">UR1</orgName>
<desc> <address> <addrLine>2 rue du Thabor - CS 46510 - 35065 Rennes cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-rennes1.fr/</ref>
</desc>
<listRelation> <relation active="#struct-528860" type="direct"></relation>
</listRelation>
</org>
</tutelle>
<tutelle active="#struct-528860" type="indirect"><org type="regroupinstitution" xml:id="struct-528860" status="VALID"> <orgName>Université de Rennes</orgName>
<orgName type="acronym">UNIV-RENNES</orgName>
<date type="start">2018-01-01</date>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-301327" type="direct"><org type="institution" xml:id="struct-301327" status="VALID"> <orgName>CHU Pontchaillou [Rennes]</orgName>
<desc> <address> <addrLine>2 Rue Henri le Guilloux, 35000 Rennes</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.chu-rennes.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-303578" type="direct"><org type="institution" xml:id="struct-303578" status="VALID"> <orgName>Faculté de Chirurgie Dentaire de Rennes</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-305263" type="direct"><org type="institution" xml:id="struct-305263" status="INCOMING"> <orgName>Faculté d'Odontologie</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-453207" type="direct"><org type="institution" xml:id="struct-453207" status="VALID"> <orgName>Structure Fédérative de Recherche en Biologie et Santé de Rennes </orgName>
<orgName type="acronym"> Biosit : Biologie - Santé - Innovation Technologique </orgName>
<desc> <address> <addrLine>Université Rennes 1 - Campus Santé Villejean - 2, avenue Professeur Léon Bernard 35043 Rennes cedex</addrLine>
<country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Rennes</settlement>
<region type="region" nuts="2">Région Bretagne</region>
</placeName>
<orgName type="university">Université de Rennes 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université européenne de Bretagne</orgName>
</affiliation>
</author>
<author><name sortKey="Flecher, Erwan" sort="Flecher, Erwan" uniqKey="Flecher E" first="Erwan" last="Flecher">Erwan Flecher</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-184350" status="VALID"> <orgName>Service de chirurgie thoracique cardiaque et vasculaire [Rennes]</orgName>
<desc> <address> <addrLine>35033 Rennes</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation> <relation active="#struct-105160" type="direct"></relation>
<relation active="#struct-528860" type="indirect"></relation>
<relation active="#struct-300129" type="direct"></relation>
<relation active="#struct-301327" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-105160" type="direct"><org type="institution" xml:id="struct-105160" status="VALID"> <orgName>Université de Rennes 1</orgName>
<orgName type="acronym">UR1</orgName>
<desc> <address> <addrLine>2 rue du Thabor - CS 46510 - 35065 Rennes cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-rennes1.fr/</ref>
</desc>
<listRelation> <relation active="#struct-528860" type="direct"></relation>
</listRelation>
</org>
</tutelle>
<tutelle active="#struct-528860" type="indirect"><org type="regroupinstitution" xml:id="struct-528860" status="VALID"> <orgName>Université de Rennes</orgName>
<orgName type="acronym">UNIV-RENNES</orgName>
<date type="start">2018-01-01</date>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300129" type="direct"><org type="institution" xml:id="struct-300129" status="VALID"> <orgName>Hôpital Pontchaillou</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-301327" type="direct"><org type="institution" xml:id="struct-301327" status="VALID"> <orgName>CHU Pontchaillou [Rennes]</orgName>
<desc> <address> <addrLine>2 Rue Henri le Guilloux, 35000 Rennes</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.chu-rennes.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Rennes</settlement>
<region type="region" nuts="2">Région Bretagne</region>
</placeName>
<orgName type="university">Université de Rennes 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université européenne de Bretagne</orgName>
</affiliation>
</author>
<author><name sortKey="Fily, Fabien" sort="Fily, Fabien" uniqKey="Fily F" first="Fabien" last="Fily">Fabien Fily</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-17929" status="VALID"> <orgName>Service des maladies infectieuses et réanimation médicale</orgName>
<desc> <address> <addrLine>2 rue Henri Le Guilloux 35033 RENNES cedex 9</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.chu-rennes.fr/</ref>
</desc>
<listRelation> <relation active="#struct-105160" type="direct"></relation>
<relation active="#struct-528860" type="indirect"></relation>
<relation active="#struct-300129" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-105160" type="direct"><org type="institution" xml:id="struct-105160" status="VALID"> <orgName>Université de Rennes 1</orgName>
<orgName type="acronym">UR1</orgName>
<desc> <address> <addrLine>2 rue du Thabor - CS 46510 - 35065 Rennes cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-rennes1.fr/</ref>
</desc>
<listRelation> <relation active="#struct-528860" type="direct"></relation>
</listRelation>
</org>
</tutelle>
<tutelle active="#struct-528860" type="indirect"><org type="regroupinstitution" xml:id="struct-528860" status="VALID"> <orgName>Université de Rennes</orgName>
<orgName type="acronym">UNIV-RENNES</orgName>
<date type="start">2018-01-01</date>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300129" type="direct"><org type="institution" xml:id="struct-300129" status="VALID"> <orgName>Hôpital Pontchaillou</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Rennes</settlement>
<region type="region" nuts="2">Région Bretagne</region>
</placeName>
<orgName type="university">Université de Rennes 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université européenne de Bretagne</orgName>
</affiliation>
</author>
<author><name sortKey="Revest, Matthieu" sort="Revest, Matthieu" uniqKey="Revest M" first="Matthieu" last="Revest">Matthieu Revest</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-17929" status="VALID"> <orgName>Service des maladies infectieuses et réanimation médicale</orgName>
<desc> <address> <addrLine>2 rue Henri Le Guilloux 35033 RENNES cedex 9</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.chu-rennes.fr/</ref>
</desc>
<listRelation> <relation active="#struct-105160" type="direct"></relation>
<relation active="#struct-528860" type="indirect"></relation>
<relation active="#struct-300129" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-105160" type="direct"><org type="institution" xml:id="struct-105160" status="VALID"> <orgName>Université de Rennes 1</orgName>
<orgName type="acronym">UR1</orgName>
<desc> <address> <addrLine>2 rue du Thabor - CS 46510 - 35065 Rennes cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-rennes1.fr/</ref>
</desc>
<listRelation> <relation active="#struct-528860" type="direct"></relation>
</listRelation>
</org>
</tutelle>
<tutelle active="#struct-528860" type="indirect"><org type="regroupinstitution" xml:id="struct-528860" status="VALID"> <orgName>Université de Rennes</orgName>
<orgName type="acronym">UNIV-RENNES</orgName>
<date type="start">2018-01-01</date>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300129" type="direct"><org type="institution" xml:id="struct-300129" status="VALID"> <orgName>Hôpital Pontchaillou</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Rennes</settlement>
<region type="region" nuts="2">Région Bretagne</region>
</placeName>
<orgName type="university">Université de Rennes 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université européenne de Bretagne</orgName>
</affiliation>
</author>
<author><name sortKey="Arvieux, Cedric" sort="Arvieux, Cedric" uniqKey="Arvieux C" first="Cédric" last="Arvieux">Cédric Arvieux</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-17929" status="VALID"> <orgName>Service des maladies infectieuses et réanimation médicale</orgName>
<desc> <address> <addrLine>2 rue Henri Le Guilloux 35033 RENNES cedex 9</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.chu-rennes.fr/</ref>
</desc>
<listRelation> <relation active="#struct-105160" type="direct"></relation>
<relation active="#struct-528860" type="indirect"></relation>
<relation active="#struct-300129" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-105160" type="direct"><org type="institution" xml:id="struct-105160" status="VALID"> <orgName>Université de Rennes 1</orgName>
<orgName type="acronym">UR1</orgName>
<desc> <address> <addrLine>2 rue du Thabor - CS 46510 - 35065 Rennes cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-rennes1.fr/</ref>
</desc>
<listRelation> <relation active="#struct-528860" type="direct"></relation>
</listRelation>
</org>
</tutelle>
<tutelle active="#struct-528860" type="indirect"><org type="regroupinstitution" xml:id="struct-528860" status="VALID"> <orgName>Université de Rennes</orgName>
<orgName type="acronym">UNIV-RENNES</orgName>
<date type="start">2018-01-01</date>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300129" type="direct"><org type="institution" xml:id="struct-300129" status="VALID"> <orgName>Hôpital Pontchaillou</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Rennes</settlement>
<region type="region" nuts="2">Région Bretagne</region>
</placeName>
<orgName type="university">Université de Rennes 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université européenne de Bretagne</orgName>
</affiliation>
</author>
<author><name sortKey="Donnio, Pierre Yves" sort="Donnio, Pierre Yves" uniqKey="Donnio P" first="Pierre-Yves" last="Donnio">Pierre-Yves Donnio</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-104640" status="OLD"> <idno type="IdRef">185720005</idno>
<idno type="ISNI">0000 0004 0450 5866 </idno>
<idno type="RNSR">199213399D</idno>
<orgName>Microbiologie : Risques Infectieux</orgName>
<date type="start">1992</date>
<date type="end">2016-12-31</date>
<desc> <address> <addrLine>UFR Sciences Pharmaceutiques et Biologiques, Département de Bactériologie Virologie et Hygiène Hospitalière - 2 avenue du Professeur Léon Bernard (Bât 15) 35043 Rennes</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://microbiologie.univ-rennes1.fr/</ref>
</desc>
<listRelation> <relation name="EA1254" active="#struct-105160" type="direct"></relation>
<relation active="#struct-528860" type="indirect"></relation>
<relation active="#struct-301327" type="direct"></relation>
<relation active="#struct-303578" type="direct"></relation>
<relation active="#struct-305263" type="direct"></relation>
<relation active="#struct-453207" type="direct"></relation>
</listRelation>
<tutelles><tutelle name="EA1254" active="#struct-105160" type="direct"><org type="institution" xml:id="struct-105160" status="VALID"> <orgName>Université de Rennes 1</orgName>
<orgName type="acronym">UR1</orgName>
<desc> <address> <addrLine>2 rue du Thabor - CS 46510 - 35065 Rennes cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-rennes1.fr/</ref>
</desc>
<listRelation> <relation active="#struct-528860" type="direct"></relation>
</listRelation>
</org>
</tutelle>
<tutelle active="#struct-528860" type="indirect"><org type="regroupinstitution" xml:id="struct-528860" status="VALID"> <orgName>Université de Rennes</orgName>
<orgName type="acronym">UNIV-RENNES</orgName>
<date type="start">2018-01-01</date>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-301327" type="direct"><org type="institution" xml:id="struct-301327" status="VALID"> <orgName>CHU Pontchaillou [Rennes]</orgName>
<desc> <address> <addrLine>2 Rue Henri le Guilloux, 35000 Rennes</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.chu-rennes.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-303578" type="direct"><org type="institution" xml:id="struct-303578" status="VALID"> <orgName>Faculté de Chirurgie Dentaire de Rennes</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-305263" type="direct"><org type="institution" xml:id="struct-305263" status="INCOMING"> <orgName>Faculté d'Odontologie</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-453207" type="direct"><org type="institution" xml:id="struct-453207" status="VALID"> <orgName>Structure Fédérative de Recherche en Biologie et Santé de Rennes </orgName>
<orgName type="acronym"> Biosit : Biologie - Santé - Innovation Technologique </orgName>
<desc> <address> <addrLine>Université Rennes 1 - Campus Santé Villejean - 2, avenue Professeur Léon Bernard 35043 Rennes cedex</addrLine>
<country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Rennes</settlement>
<region type="region" nuts="2">Région Bretagne</region>
</placeName>
<orgName type="university">Université de Rennes 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université européenne de Bretagne</orgName>
</affiliation>
</author>
<author><name sortKey="Michelet, Christian" sort="Michelet, Christian" uniqKey="Michelet C" first="Christian" last="Michelet">Christian Michelet</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-17929" status="VALID"> <orgName>Service des maladies infectieuses et réanimation médicale</orgName>
<desc> <address> <addrLine>2 rue Henri Le Guilloux 35033 RENNES cedex 9</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.chu-rennes.fr/</ref>
</desc>
<listRelation> <relation active="#struct-105160" type="direct"></relation>
<relation active="#struct-528860" type="indirect"></relation>
<relation active="#struct-300129" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-105160" type="direct"><org type="institution" xml:id="struct-105160" status="VALID"> <orgName>Université de Rennes 1</orgName>
<orgName type="acronym">UR1</orgName>
<desc> <address> <addrLine>2 rue du Thabor - CS 46510 - 35065 Rennes cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-rennes1.fr/</ref>
</desc>
<listRelation> <relation active="#struct-528860" type="direct"></relation>
</listRelation>
</org>
</tutelle>
<tutelle active="#struct-528860" type="indirect"><org type="regroupinstitution" xml:id="struct-528860" status="VALID"> <orgName>Université de Rennes</orgName>
<orgName type="acronym">UNIV-RENNES</orgName>
<date type="start">2018-01-01</date>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300129" type="direct"><org type="institution" xml:id="struct-300129" status="VALID"> <orgName>Hôpital Pontchaillou</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Rennes</settlement>
<region type="region" nuts="2">Région Bretagne</region>
</placeName>
<orgName type="university">Université de Rennes 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université européenne de Bretagne</orgName>
</affiliation>
</author>
<author><name sortKey="Tattevin, Pierre" sort="Tattevin, Pierre" uniqKey="Tattevin P" first="Pierre" last="Tattevin">Pierre Tattevin</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-17929" status="VALID"> <orgName>Service des maladies infectieuses et réanimation médicale</orgName>
<desc> <address> <addrLine>2 rue Henri Le Guilloux 35033 RENNES cedex 9</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.chu-rennes.fr/</ref>
</desc>
<listRelation> <relation active="#struct-105160" type="direct"></relation>
<relation active="#struct-528860" type="indirect"></relation>
<relation active="#struct-300129" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-105160" type="direct"><org type="institution" xml:id="struct-105160" status="VALID"> <orgName>Université de Rennes 1</orgName>
<orgName type="acronym">UR1</orgName>
<desc> <address> <addrLine>2 rue du Thabor - CS 46510 - 35065 Rennes cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-rennes1.fr/</ref>
</desc>
<listRelation> <relation active="#struct-528860" type="direct"></relation>
</listRelation>
</org>
</tutelle>
<tutelle active="#struct-528860" type="indirect"><org type="regroupinstitution" xml:id="struct-528860" status="VALID"> <orgName>Université de Rennes</orgName>
<orgName type="acronym">UNIV-RENNES</orgName>
<date type="start">2018-01-01</date>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300129" type="direct"><org type="institution" xml:id="struct-300129" status="VALID"> <orgName>Hôpital Pontchaillou</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Rennes</settlement>
<region type="region" nuts="2">Région Bretagne</region>
</placeName>
<orgName type="university">Université de Rennes 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université européenne de Bretagne</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">HAL</idno>
<idno type="RBID">Hal:hal-00759192</idno>
<idno type="halId">hal-00759192</idno>
<idno type="halUri">https://hal.archives-ouvertes.fr/hal-00759192</idno>
<idno type="url">https://hal.archives-ouvertes.fr/hal-00759192</idno>
<idno type="doi">10.1016/j.amjmed.2010.04.030</idno>
<date when="2010-10">2010-10</date>
<idno type="wicri:Area/Hal/Corpus">000215</idno>
<idno type="wicri:Area/Hal/Curation">000215</idno>
<idno type="wicri:Area/Hal/Checkpoint">000177</idno>
<idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000177</idno>
<idno type="wicri:Area/Main/Merge">001605</idno>
<idno type="wicri:Area/Main/Curation">001603</idno>
<idno type="wicri:Area/Main/Exploration">001603</idno>
<idno type="wicri:Area/France/Extraction">000245</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Should we systematically perform central nervous system imaging in patients with Whipple's endocarditis?</title>
<author><name sortKey="Besnard, Sophie" sort="Besnard, Sophie" uniqKey="Besnard S" first="Sophie" last="Besnard">Sophie Besnard</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-17929" status="VALID"> <orgName>Service des maladies infectieuses et réanimation médicale</orgName>
<desc> <address> <addrLine>2 rue Henri Le Guilloux 35033 RENNES cedex 9</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.chu-rennes.fr/</ref>
</desc>
<listRelation> <relation active="#struct-105160" type="direct"></relation>
<relation active="#struct-528860" type="indirect"></relation>
<relation active="#struct-300129" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-105160" type="direct"><org type="institution" xml:id="struct-105160" status="VALID"> <orgName>Université de Rennes 1</orgName>
<orgName type="acronym">UR1</orgName>
<desc> <address> <addrLine>2 rue du Thabor - CS 46510 - 35065 Rennes cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-rennes1.fr/</ref>
</desc>
<listRelation> <relation active="#struct-528860" type="direct"></relation>
</listRelation>
</org>
</tutelle>
<tutelle active="#struct-528860" type="indirect"><org type="regroupinstitution" xml:id="struct-528860" status="VALID"> <orgName>Université de Rennes</orgName>
<orgName type="acronym">UNIV-RENNES</orgName>
<date type="start">2018-01-01</date>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300129" type="direct"><org type="institution" xml:id="struct-300129" status="VALID"> <orgName>Hôpital Pontchaillou</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Rennes</settlement>
<region type="region" nuts="2">Région Bretagne</region>
</placeName>
<orgName type="university">Université de Rennes 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université européenne de Bretagne</orgName>
</affiliation>
</author>
<author><name sortKey="Cady, Anne" sort="Cady, Anne" uniqKey="Cady A" first="Anne" last="Cady">Anne Cady</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-104640" status="OLD"> <idno type="IdRef">185720005</idno>
<idno type="ISNI">0000 0004 0450 5866 </idno>
<idno type="RNSR">199213399D</idno>
<orgName>Microbiologie : Risques Infectieux</orgName>
<date type="start">1992</date>
<date type="end">2016-12-31</date>
<desc> <address> <addrLine>UFR Sciences Pharmaceutiques et Biologiques, Département de Bactériologie Virologie et Hygiène Hospitalière - 2 avenue du Professeur Léon Bernard (Bât 15) 35043 Rennes</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://microbiologie.univ-rennes1.fr/</ref>
</desc>
<listRelation> <relation name="EA1254" active="#struct-105160" type="direct"></relation>
<relation active="#struct-528860" type="indirect"></relation>
<relation active="#struct-301327" type="direct"></relation>
<relation active="#struct-303578" type="direct"></relation>
<relation active="#struct-305263" type="direct"></relation>
<relation active="#struct-453207" type="direct"></relation>
</listRelation>
<tutelles><tutelle name="EA1254" active="#struct-105160" type="direct"><org type="institution" xml:id="struct-105160" status="VALID"> <orgName>Université de Rennes 1</orgName>
<orgName type="acronym">UR1</orgName>
<desc> <address> <addrLine>2 rue du Thabor - CS 46510 - 35065 Rennes cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-rennes1.fr/</ref>
</desc>
<listRelation> <relation active="#struct-528860" type="direct"></relation>
</listRelation>
</org>
</tutelle>
<tutelle active="#struct-528860" type="indirect"><org type="regroupinstitution" xml:id="struct-528860" status="VALID"> <orgName>Université de Rennes</orgName>
<orgName type="acronym">UNIV-RENNES</orgName>
<date type="start">2018-01-01</date>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-301327" type="direct"><org type="institution" xml:id="struct-301327" status="VALID"> <orgName>CHU Pontchaillou [Rennes]</orgName>
<desc> <address> <addrLine>2 Rue Henri le Guilloux, 35000 Rennes</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.chu-rennes.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-303578" type="direct"><org type="institution" xml:id="struct-303578" status="VALID"> <orgName>Faculté de Chirurgie Dentaire de Rennes</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-305263" type="direct"><org type="institution" xml:id="struct-305263" status="INCOMING"> <orgName>Faculté d'Odontologie</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-453207" type="direct"><org type="institution" xml:id="struct-453207" status="VALID"> <orgName>Structure Fédérative de Recherche en Biologie et Santé de Rennes </orgName>
<orgName type="acronym"> Biosit : Biologie - Santé - Innovation Technologique </orgName>
<desc> <address> <addrLine>Université Rennes 1 - Campus Santé Villejean - 2, avenue Professeur Léon Bernard 35043 Rennes cedex</addrLine>
<country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Rennes</settlement>
<region type="region" nuts="2">Région Bretagne</region>
</placeName>
<orgName type="university">Université de Rennes 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université européenne de Bretagne</orgName>
</affiliation>
</author>
<author><name sortKey="Flecher, Erwan" sort="Flecher, Erwan" uniqKey="Flecher E" first="Erwan" last="Flecher">Erwan Flecher</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-184350" status="VALID"> <orgName>Service de chirurgie thoracique cardiaque et vasculaire [Rennes]</orgName>
<desc> <address> <addrLine>35033 Rennes</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation> <relation active="#struct-105160" type="direct"></relation>
<relation active="#struct-528860" type="indirect"></relation>
<relation active="#struct-300129" type="direct"></relation>
<relation active="#struct-301327" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-105160" type="direct"><org type="institution" xml:id="struct-105160" status="VALID"> <orgName>Université de Rennes 1</orgName>
<orgName type="acronym">UR1</orgName>
<desc> <address> <addrLine>2 rue du Thabor - CS 46510 - 35065 Rennes cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-rennes1.fr/</ref>
</desc>
<listRelation> <relation active="#struct-528860" type="direct"></relation>
</listRelation>
</org>
</tutelle>
<tutelle active="#struct-528860" type="indirect"><org type="regroupinstitution" xml:id="struct-528860" status="VALID"> <orgName>Université de Rennes</orgName>
<orgName type="acronym">UNIV-RENNES</orgName>
<date type="start">2018-01-01</date>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300129" type="direct"><org type="institution" xml:id="struct-300129" status="VALID"> <orgName>Hôpital Pontchaillou</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-301327" type="direct"><org type="institution" xml:id="struct-301327" status="VALID"> <orgName>CHU Pontchaillou [Rennes]</orgName>
<desc> <address> <addrLine>2 Rue Henri le Guilloux, 35000 Rennes</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.chu-rennes.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Rennes</settlement>
<region type="region" nuts="2">Région Bretagne</region>
</placeName>
<orgName type="university">Université de Rennes 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université européenne de Bretagne</orgName>
</affiliation>
</author>
<author><name sortKey="Fily, Fabien" sort="Fily, Fabien" uniqKey="Fily F" first="Fabien" last="Fily">Fabien Fily</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-17929" status="VALID"> <orgName>Service des maladies infectieuses et réanimation médicale</orgName>
<desc> <address> <addrLine>2 rue Henri Le Guilloux 35033 RENNES cedex 9</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.chu-rennes.fr/</ref>
</desc>
<listRelation> <relation active="#struct-105160" type="direct"></relation>
<relation active="#struct-528860" type="indirect"></relation>
<relation active="#struct-300129" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-105160" type="direct"><org type="institution" xml:id="struct-105160" status="VALID"> <orgName>Université de Rennes 1</orgName>
<orgName type="acronym">UR1</orgName>
<desc> <address> <addrLine>2 rue du Thabor - CS 46510 - 35065 Rennes cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-rennes1.fr/</ref>
</desc>
<listRelation> <relation active="#struct-528860" type="direct"></relation>
</listRelation>
</org>
</tutelle>
<tutelle active="#struct-528860" type="indirect"><org type="regroupinstitution" xml:id="struct-528860" status="VALID"> <orgName>Université de Rennes</orgName>
<orgName type="acronym">UNIV-RENNES</orgName>
<date type="start">2018-01-01</date>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300129" type="direct"><org type="institution" xml:id="struct-300129" status="VALID"> <orgName>Hôpital Pontchaillou</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Rennes</settlement>
<region type="region" nuts="2">Région Bretagne</region>
</placeName>
<orgName type="university">Université de Rennes 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université européenne de Bretagne</orgName>
</affiliation>
</author>
<author><name sortKey="Revest, Matthieu" sort="Revest, Matthieu" uniqKey="Revest M" first="Matthieu" last="Revest">Matthieu Revest</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-17929" status="VALID"> <orgName>Service des maladies infectieuses et réanimation médicale</orgName>
<desc> <address> <addrLine>2 rue Henri Le Guilloux 35033 RENNES cedex 9</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.chu-rennes.fr/</ref>
</desc>
<listRelation> <relation active="#struct-105160" type="direct"></relation>
<relation active="#struct-528860" type="indirect"></relation>
<relation active="#struct-300129" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-105160" type="direct"><org type="institution" xml:id="struct-105160" status="VALID"> <orgName>Université de Rennes 1</orgName>
<orgName type="acronym">UR1</orgName>
<desc> <address> <addrLine>2 rue du Thabor - CS 46510 - 35065 Rennes cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-rennes1.fr/</ref>
</desc>
<listRelation> <relation active="#struct-528860" type="direct"></relation>
</listRelation>
</org>
</tutelle>
<tutelle active="#struct-528860" type="indirect"><org type="regroupinstitution" xml:id="struct-528860" status="VALID"> <orgName>Université de Rennes</orgName>
<orgName type="acronym">UNIV-RENNES</orgName>
<date type="start">2018-01-01</date>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300129" type="direct"><org type="institution" xml:id="struct-300129" status="VALID"> <orgName>Hôpital Pontchaillou</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Rennes</settlement>
<region type="region" nuts="2">Région Bretagne</region>
</placeName>
<orgName type="university">Université de Rennes 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université européenne de Bretagne</orgName>
</affiliation>
</author>
<author><name sortKey="Arvieux, Cedric" sort="Arvieux, Cedric" uniqKey="Arvieux C" first="Cédric" last="Arvieux">Cédric Arvieux</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-17929" status="VALID"> <orgName>Service des maladies infectieuses et réanimation médicale</orgName>
<desc> <address> <addrLine>2 rue Henri Le Guilloux 35033 RENNES cedex 9</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.chu-rennes.fr/</ref>
</desc>
<listRelation> <relation active="#struct-105160" type="direct"></relation>
<relation active="#struct-528860" type="indirect"></relation>
<relation active="#struct-300129" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-105160" type="direct"><org type="institution" xml:id="struct-105160" status="VALID"> <orgName>Université de Rennes 1</orgName>
<orgName type="acronym">UR1</orgName>
<desc> <address> <addrLine>2 rue du Thabor - CS 46510 - 35065 Rennes cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-rennes1.fr/</ref>
</desc>
<listRelation> <relation active="#struct-528860" type="direct"></relation>
</listRelation>
</org>
</tutelle>
<tutelle active="#struct-528860" type="indirect"><org type="regroupinstitution" xml:id="struct-528860" status="VALID"> <orgName>Université de Rennes</orgName>
<orgName type="acronym">UNIV-RENNES</orgName>
<date type="start">2018-01-01</date>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300129" type="direct"><org type="institution" xml:id="struct-300129" status="VALID"> <orgName>Hôpital Pontchaillou</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Rennes</settlement>
<region type="region" nuts="2">Région Bretagne</region>
</placeName>
<orgName type="university">Université de Rennes 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université européenne de Bretagne</orgName>
</affiliation>
</author>
<author><name sortKey="Donnio, Pierre Yves" sort="Donnio, Pierre Yves" uniqKey="Donnio P" first="Pierre-Yves" last="Donnio">Pierre-Yves Donnio</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-104640" status="OLD"> <idno type="IdRef">185720005</idno>
<idno type="ISNI">0000 0004 0450 5866 </idno>
<idno type="RNSR">199213399D</idno>
<orgName>Microbiologie : Risques Infectieux</orgName>
<date type="start">1992</date>
<date type="end">2016-12-31</date>
<desc> <address> <addrLine>UFR Sciences Pharmaceutiques et Biologiques, Département de Bactériologie Virologie et Hygiène Hospitalière - 2 avenue du Professeur Léon Bernard (Bât 15) 35043 Rennes</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://microbiologie.univ-rennes1.fr/</ref>
</desc>
<listRelation> <relation name="EA1254" active="#struct-105160" type="direct"></relation>
<relation active="#struct-528860" type="indirect"></relation>
<relation active="#struct-301327" type="direct"></relation>
<relation active="#struct-303578" type="direct"></relation>
<relation active="#struct-305263" type="direct"></relation>
<relation active="#struct-453207" type="direct"></relation>
</listRelation>
<tutelles><tutelle name="EA1254" active="#struct-105160" type="direct"><org type="institution" xml:id="struct-105160" status="VALID"> <orgName>Université de Rennes 1</orgName>
<orgName type="acronym">UR1</orgName>
<desc> <address> <addrLine>2 rue du Thabor - CS 46510 - 35065 Rennes cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-rennes1.fr/</ref>
</desc>
<listRelation> <relation active="#struct-528860" type="direct"></relation>
</listRelation>
</org>
</tutelle>
<tutelle active="#struct-528860" type="indirect"><org type="regroupinstitution" xml:id="struct-528860" status="VALID"> <orgName>Université de Rennes</orgName>
<orgName type="acronym">UNIV-RENNES</orgName>
<date type="start">2018-01-01</date>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-301327" type="direct"><org type="institution" xml:id="struct-301327" status="VALID"> <orgName>CHU Pontchaillou [Rennes]</orgName>
<desc> <address> <addrLine>2 Rue Henri le Guilloux, 35000 Rennes</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.chu-rennes.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-303578" type="direct"><org type="institution" xml:id="struct-303578" status="VALID"> <orgName>Faculté de Chirurgie Dentaire de Rennes</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-305263" type="direct"><org type="institution" xml:id="struct-305263" status="INCOMING"> <orgName>Faculté d'Odontologie</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-453207" type="direct"><org type="institution" xml:id="struct-453207" status="VALID"> <orgName>Structure Fédérative de Recherche en Biologie et Santé de Rennes </orgName>
<orgName type="acronym"> Biosit : Biologie - Santé - Innovation Technologique </orgName>
<desc> <address> <addrLine>Université Rennes 1 - Campus Santé Villejean - 2, avenue Professeur Léon Bernard 35043 Rennes cedex</addrLine>
<country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Rennes</settlement>
<region type="region" nuts="2">Région Bretagne</region>
</placeName>
<orgName type="university">Université de Rennes 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université européenne de Bretagne</orgName>
</affiliation>
</author>
<author><name sortKey="Michelet, Christian" sort="Michelet, Christian" uniqKey="Michelet C" first="Christian" last="Michelet">Christian Michelet</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-17929" status="VALID"> <orgName>Service des maladies infectieuses et réanimation médicale</orgName>
<desc> <address> <addrLine>2 rue Henri Le Guilloux 35033 RENNES cedex 9</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.chu-rennes.fr/</ref>
</desc>
<listRelation> <relation active="#struct-105160" type="direct"></relation>
<relation active="#struct-528860" type="indirect"></relation>
<relation active="#struct-300129" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-105160" type="direct"><org type="institution" xml:id="struct-105160" status="VALID"> <orgName>Université de Rennes 1</orgName>
<orgName type="acronym">UR1</orgName>
<desc> <address> <addrLine>2 rue du Thabor - CS 46510 - 35065 Rennes cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-rennes1.fr/</ref>
</desc>
<listRelation> <relation active="#struct-528860" type="direct"></relation>
</listRelation>
</org>
</tutelle>
<tutelle active="#struct-528860" type="indirect"><org type="regroupinstitution" xml:id="struct-528860" status="VALID"> <orgName>Université de Rennes</orgName>
<orgName type="acronym">UNIV-RENNES</orgName>
<date type="start">2018-01-01</date>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300129" type="direct"><org type="institution" xml:id="struct-300129" status="VALID"> <orgName>Hôpital Pontchaillou</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Rennes</settlement>
<region type="region" nuts="2">Région Bretagne</region>
</placeName>
<orgName type="university">Université de Rennes 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université européenne de Bretagne</orgName>
</affiliation>
</author>
<author><name sortKey="Tattevin, Pierre" sort="Tattevin, Pierre" uniqKey="Tattevin P" first="Pierre" last="Tattevin">Pierre Tattevin</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-17929" status="VALID"> <orgName>Service des maladies infectieuses et réanimation médicale</orgName>
<desc> <address> <addrLine>2 rue Henri Le Guilloux 35033 RENNES cedex 9</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.chu-rennes.fr/</ref>
</desc>
<listRelation> <relation active="#struct-105160" type="direct"></relation>
<relation active="#struct-528860" type="indirect"></relation>
<relation active="#struct-300129" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-105160" type="direct"><org type="institution" xml:id="struct-105160" status="VALID"> <orgName>Université de Rennes 1</orgName>
<orgName type="acronym">UR1</orgName>
<desc> <address> <addrLine>2 rue du Thabor - CS 46510 - 35065 Rennes cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-rennes1.fr/</ref>
</desc>
<listRelation> <relation active="#struct-528860" type="direct"></relation>
</listRelation>
</org>
</tutelle>
<tutelle active="#struct-528860" type="indirect"><org type="regroupinstitution" xml:id="struct-528860" status="VALID"> <orgName>Université de Rennes</orgName>
<orgName type="acronym">UNIV-RENNES</orgName>
<date type="start">2018-01-01</date>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300129" type="direct"><org type="institution" xml:id="struct-300129" status="VALID"> <orgName>Hôpital Pontchaillou</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Rennes</settlement>
<region type="region" nuts="2">Région Bretagne</region>
</placeName>
<orgName type="university">Université de Rennes 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université européenne de Bretagne</orgName>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1016/j.amjmed.2010.04.030</idno>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>16S rRNA</term>
<term>Central nervous system</term>
<term>Infective endocarditis</term>
<term>Tropheryma whipplei</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"> <p>BACKGROUND: Whipple's endocarditis is an uncommon disease, with approximately 100 cases reported to date. Case series suggest that Whipple's endocarditis usually presents without extracardiac manifestations of Whipple's disease. METHODS: We report 4 consecutive cases of Whipple's endocarditis associated with brain lesions. All patients fulfilled Duke Criteria for definite endocarditis. Whipple's disease was diagnosed through 16S rRNA polymerase chain reaction assays on valves excised from patients with culture-negative endocarditis (n=3) or through polymerase chain reaction and periodic acid staining-positive foamy macrophages on duodenal biopsy (n=1). RESULTS: All patients were male, aged 56 to 72 years. They presented with mitral (n=1), aortic (n=1), mitral and aortic (n=1), and tricuspid (n=1) endocarditis. Brain magnetic resonance imaging was performed because of mild-to-moderate cognitive disorders (n=3) or ataxia (n=1) and revealed multiple (n=3) or solitary (n=1) contrast-enhancing lesions. Cerebrospinal fluid studies revealed meningitis in 1 case. Polymerase chain reaction assays on cerebrospinal fluid were negative for all patients. All patients received intravenous ceftriaxone (2-4 weeks) associated with gentamicin (2 weeks), followed by 1 year of oral trimethoprim-sulfamethoxazole, with favorable outcomes. CONCLUSION: Whipple's associated central nervous system disease may be common but frequently undiagnosed, in patients with Whipple's endocarditis. Because treatment is different when neurologic disease is present (ie, trimethoprim-sulfamethoxazole vs doxycycline/hydroxychloroquine), clinicians should consider brain imaging in patients diagnosed with Whipple's endocarditis.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
<region><li>Région Bretagne</li>
</region>
<settlement><li>Rennes</li>
</settlement>
<orgName><li>Université de Rennes 1</li>
<li>Université européenne de Bretagne</li>
</orgName>
</list>
<tree><country name="France"><region name="Région Bretagne"><name sortKey="Besnard, Sophie" sort="Besnard, Sophie" uniqKey="Besnard S" first="Sophie" last="Besnard">Sophie Besnard</name>
</region>
<name sortKey="Arvieux, Cedric" sort="Arvieux, Cedric" uniqKey="Arvieux C" first="Cédric" last="Arvieux">Cédric Arvieux</name>
<name sortKey="Cady, Anne" sort="Cady, Anne" uniqKey="Cady A" first="Anne" last="Cady">Anne Cady</name>
<name sortKey="Donnio, Pierre Yves" sort="Donnio, Pierre Yves" uniqKey="Donnio P" first="Pierre-Yves" last="Donnio">Pierre-Yves Donnio</name>
<name sortKey="Fily, Fabien" sort="Fily, Fabien" uniqKey="Fily F" first="Fabien" last="Fily">Fabien Fily</name>
<name sortKey="Flecher, Erwan" sort="Flecher, Erwan" uniqKey="Flecher E" first="Erwan" last="Flecher">Erwan Flecher</name>
<name sortKey="Michelet, Christian" sort="Michelet, Christian" uniqKey="Michelet C" first="Christian" last="Michelet">Christian Michelet</name>
<name sortKey="Revest, Matthieu" sort="Revest, Matthieu" uniqKey="Revest M" first="Matthieu" last="Revest">Matthieu Revest</name>
<name sortKey="Tattevin, Pierre" sort="Tattevin, Pierre" uniqKey="Tattevin P" first="Pierre" last="Tattevin">Pierre Tattevin</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/France/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000245 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000245 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= ChloroquineV1 |flux= France |étape= Analysis |type= RBID |clé= Hal:hal-00759192 |texte= Should we systematically perform central nervous system imaging in patients with Whipple's endocarditis? }}
This area was generated with Dilib version V0.6.33. |